For a large oil- and gas-producing company we completed the application of an "umbrella permit" for over 200 chemicals used in the off-shore industry. This project involved gathering and evaluating data from HOCNF (Harmonized Offshore Chemical Notification Format) forms, Material safety data sheets (MSDS) and CEFAS (Centre for Environment, Fisheries & Aquaculture Science) templates, as well as using the model CHARM.
IUCLID 5 data entry
For various chemical companies we search the scientific literature databases and retrieve data study reports, etc. After evaluation, we link the data to the data requirements under REACH or other legislation. The data are translated into study endpoint records according to the format of IUCLID 5. This includes the critical review of data with regard to scientific value, reliability (Klimisch-criteria) and relevance. Chemicals Management also offers training courses for IUCLID 5.
General assessment methodology of chemicals
For a large chemical producing company we evaluated the risk to the aquatic environment (according to the Dutch ABM) of over 800 chemicals. This project consisted of gathering and reviewing data on classification and labeling, mutagenicity, biodegradability and bioaccumulation (or log Kow), as well as aquatic toxicity. The use of read-cross and (Q)SAR's such as EPIWIN and ECOSAR, enabled us to fill many data gaps using a solid scientific basis.
Toxicity of metals
For the Dutch Institute for Inland Water Management and Waste Water Treatment RIZA we investigated the toxic effects of so-called rare earth metals on a range of aquatic organisms (bacteria, algae, invertebrates, fish). The project consisted of gathering and thoroughly reviewing scientific literature on the toxicity of metals. Results were presented in a convenient and clear table.